A Matching Adjusted Indirect Comparison Of Sonidegib And Vismodegib In Advanced Basal Cell Carcinoma
نویسندگان
چکیده
منابع مشابه
A Matching-Adjusted Indirect Comparison of Sonidegib and Vismodegib in Advanced Basal Cell Carcinoma
OBJECTIVES Based on single-arm trial data (BOLT), sonidegib was approved in the US and EU to treat locally advanced basal cell carcinomas (BCCs) ineligible for curative surgery or radiotherapy. Vismodegib, the other approved targeted therapy, also was assessed in a single-arm trial (ERIVANCE). We examined the comparative effectiveness of the two drugs using a matching-adjusted indirect comparis...
متن کاملIntracranial regression of an advanced basal cell carcinoma using sonidegib and itraconazole after failure with vismodegib
BCC: basal cell carcinoma Hh: hedgehog HIV: human immunodeficiency virus SMO: smoothened protein INTRODUCTION Locally advanced or metastatic basal cell carcinoma (BCC) has traditionally been difficult to treat. Options for unresectable tumors have been limited to cisplatin-based chemotherapy or palliative radiation therapy. With the advent of molecularly targeted drugs to the hedgehog (Hh) path...
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Vismodegib (Erivedge) for advanced basal cell carcinoma.
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BACKGROUND Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell carcinomas are treated surgically, no effective therapy exists for locally advanced or metastatic basal-cell carcinoma. A phase 1 study of vismodegib (GDC-0449), a first-in-class, small-molecule inhibitor of the hedgehog pathway, showed a 58% response rate among pati...
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Basal-cell carcinoma is a commonly occurring skin malignancy that has the potential to progress into locally invasive or resistant disease, as well as spread distantly. Due to advances in the molecular understanding of the disease over the last two decades, it has been discovered that the Hedgehog pathway plays an important role in the pathogenesis of this disease and can be exploited as a trea...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2016
ISSN: 1098-3015
DOI: 10.1016/j.jval.2016.03.492